Medellín runs north-south along the floor of the Aburrá Valley, and gravity decides more than it should. The metro is the spine, the hills hold the comunas that stack up on either side, and almost nothing you care about as a visitor sits west of the river. Once you internalize that, the city stops feeling confusing.
What follows is where to actually sleep. Five neighborhoods cover the realistic spread — from the nomad-saturated grid of El Poblado to the quieter, cheaper, more Colombian side of Belén. None of them are perfect. A couple are openly overrated. One is genuinely underrated and I'd ask you to not tell too many people.